
The ganglion cells give information about ambient light levels, and react sluggishly compared to the rods and cones. Light entering the eye strikes three different photoreceptors in the retina: the familiar rods and cones used in image forming and the more newly discovered photosensitive ganglion cells.

In some rare cases, when exposed to mustard gas.Pilocarpine eye drops and all other parasympathomimetics.Mirtazapine, a noradrenergic and specific serotonergic antidepressant ( NaSSA).Some cancer chemotherapy drugs, including camptothecin derivatives.Serotonin antagonists, such as Ondansetron (an anti-emetic) known by its brand name Zofran.Cholinergic agents such as acetylcholine.Antipsychotics, including risperidone, haloperidol, chlorpromazine, olanzapine, quetiapine.Imidazolines such as clonidine, naphazoline, oxymetazoline and tetrahydrozoline.Products containing nicotine such as cigarettes, chewing tobacco or gum.Opioids such as fentanyl, morphine, heroin and methadone (the notable exception being pethidine).Hemorrhage into pons ( intracranial hemorrhage).Senile miosis (a reduction in the size of a person's pupil in old age).Anisocoria is the condition of one pupil being more dilated than the other. The opposite condition, mydriasis, is the dilation of the pupil. Miosis, or myosis (from Ancient Greek μύειν ( múein) 'to close the eyes'), is excessive constriction of the pupil.
